Advanced Search

Submit Online

Research Highlights

< Previous         Next >  
Innate immune cells cast an eye on DNA Free
Leif E. Sander and J. Magarian Blander*
Department of Medicine, Immunology Institute, Mount Sinai School of Medicine, 1425 Madison Avenue, New York, NY 10029, USA *Correspondence to:J. Magarian Blander, E-mail: julie.blander@mssm.edu
J Mol Cell Biol, Volume 1, Issue 2, December 2009, 77-79,  https://doi.org/10.1093/jmcb/mjp023

The threonine phosphatase eyes absent (EYA) has been identified as a novel regulator of innate immune responses to cytosolic nucleic acids and undigested DNA from apoptotic cells. EYA regulates responses of yet unidentified DNA sensors and enhances interferon-β and CXCL10 transcription.

Volume 1, Issue 2
December 2009